Structure of PDB 2oyt Chain A

Receptor sequence
>2oytA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL
3D structure
PDB2oyt Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D145 Y147 F158 H268
Catalytic site (residue number reindexed from 1) D64 Y66 F77 H187
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D145 H148 P167 P168 S169 G246 S247 H268 S270 P271 L272 S273 R276 D64 H67 P86 P87 S88 G165 S166 H187 S189 P190 L191 S192 R195
BS02 dna A L272 Y275 L191 Y194
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2oyt, PDBe:2oyt, PDBj:2oyt
PDBsum2oyt
PubMed17704764
UniProtP13051|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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