Structure of PDB 2owz Chain A

Receptor sequence
>2owzA (length=315) Species: 562 (Escherichia coli) [Search protein sequence]
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLQKLDL
FANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSN
IDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTML
VYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGV
KKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPD
GKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDH
MVEDVERFIREFPDA
3D structure
PDB2owz Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state.
ChainA
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D66 E89 E90 D110 L112 D113 E275
Catalytic site (residue number reindexed from 1) D49 E72 E73 D93 L95 D96 E258
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P A D113 N206 Y239 L243 Y257 Y259 K269 E275 D96 N189 Y222 L226 Y240 Y242 K252 E258
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0030388 fructose 1,6-bisphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2owz, PDBe:2owz, PDBj:2owz
PDBsum2owz
PubMed17314096
UniProtP0A993|F16PA_ECOLI Fructose-1,6-bisphosphatase class 1 (Gene Name=fbp)

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