Structure of PDB 2os3 Chain A

Receptor sequence
>2os3A (length=205) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence]
SAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDILLGEKMMQ
FLKHSQDPVMAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPK
EAYSWQEVLYNPKIVSHSVQDAALSDGEGCLSVDRVVEGYVVRHARVTVD
YYDKEGQQHRIKLKGYNAIVVQHEIDHINGVLFYDRINAKNPFETKEELL
ILDLE
3D structure
PDB2os3 Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes
ChainA
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G72 Q77 C131 L132 H174 E175 H178
Catalytic site (residue number reindexed from 1) G71 Q76 C130 L131 H173 E174 H177
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A Q77 C131 H174 H178 Q76 C130 H173 H177
BS02 BB2 A G70 V71 G72 Q77 L125 E129 G130 C131 L132 Y167 I170 H174 E175 H178 G69 V70 G71 Q76 L124 E128 G129 C130 L131 Y166 I169 H173 E174 H177
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

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Molecular Function
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Biological Process
External links
PDB RCSB:2os3, PDBe:2os3, PDBj:2os3
PDBsum2os3
PubMed
UniProtP68771|DEF_STRP1 Peptide deformylase (Gene Name=def)

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