Structure of PDB 2oq5 Chain A

Receptor sequence
>2oq5A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPA
RWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTN
AVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATT
CNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGI
VSWGDECAKPNKPGVYTRVTALRDWITSKTGI
3D structure
PDB2oq5 Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family.
ChainA
Resolution1.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D86 Q179 G180 D181 S182 G183
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEN A D189 A190 S195 V213 W215 E218 D176 A177 S182 V201 W203 E206
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2oq5, PDBe:2oq5, PDBj:2oq5
PDBsum2oq5
PubMed17388811
UniProtQ9UL52|TM11E_HUMAN Transmembrane protease serine 11E (Gene Name=TMPRSS11E)

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