Structure of PDB 2opx Chain A

Receptor sequence
>2opxA (length=477) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence]
VPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDA
AERAQPEWEALPAIERASWLRKISAGIRERATEISALIVEEGGKIQQLAE
VEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPW
NFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVF
NLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLEL
GGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFV
NRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVA
LGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEEAIS
MANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGW
RKSGIGGADGKHGLHEYLQTQVVYLQS
3D structure
PDB2opx Crystal Structure of Lactaldehyde Dehydrogenase from Escherichia coli
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N153 K176 E251 C285 E383 A460
Catalytic site (residue number reindexed from 1) N151 K174 E249 C283 E381 A458
Enzyme Commision number 1.2.1.21: glycolaldehyde dehydrogenase.
1.2.1.22: lactaldehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXC A F107 F154 N286 F442 E443 F105 F152 N284 F440 E441
BS02 DXC A F314 G315 R320 Y364 F312 G313 R318 Y362
BS03 DXC A D322 I323 A324 F442 D320 I321 A322 F440
Gene Ontology
Molecular Function
GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0008911 lactaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0050569 glycolaldehyde dehydrogenase (NAD+) activity
Biological Process
GO:0009450 gamma-aminobutyric acid catabolic process
GO:0019301 rhamnose catabolic process
GO:0019317 fucose catabolic process
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Cellular Component
External links
PDB RCSB:2opx, PDBe:2opx, PDBj:2opx
PDBsum2opx
PubMed
UniProtP25553|ALDA_ECOLI Lactaldehyde dehydrogenase (Gene Name=aldA)

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