Structure of PDB 2oo0 Chain A

Receptor sequence
>2oo0A (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
AGENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAF
YVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCA
SKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELM
KVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNID
VVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNI
IAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSS
SIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRP
TIYYVMSGPAWQLMQQFQN
3D structure
PDB2oo0 A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K79 H207 E284
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A A67 K69 D88 H197 S200 G237 E274 G276 R277 Y389 A77 K79 D98 H207 S210 G247 E284 G286 R287 Y386 MOAD: Kd=0.05uM
BS02 XAP A C164 D332 Y389 C174 D329 Y386 MOAD: Ki=1.4nM
BS03 N2P A P239 G240 S241 V244 R277 N385 P249 G250 S251 V254 R287 N382
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oo0, PDBe:2oo0, PDBj:2oo0
PDBsum2oo0
PubMed17407445
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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