Structure of PDB 2ony Chain A

Receptor sequence
>2onyA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGR
TLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNW
SMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPL
PADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYL
AGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVF
FAWAQKV
3D structure
PDB2ony Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y27 Y35 Y40 G79 S80 T83 Y85 D101 F102 L103 D158 V159 H160 A181 F182 C183 V187 Y4 Y12 Y17 G56 S57 T60 Y62 D78 F79 L80 D135 V136 H137 A158 F159 C160 V164
BS02 TMJ A Y35 N39 Y40 R44 G54 K57 Y126 F182 E219 Y222 Y12 N16 Y17 R21 G31 K34 Y103 F159 E196 Y199 PDBbind-CN: -logKd/Ki=6.68,Ki=210nM
BindingDB: Ki=210nM
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ony, PDBe:2ony, PDBj:2ony
PDBsum2ony
PubMed17845018
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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