Structure of PDB 2onj Chain A

Receptor sequence

>2onjA (length=578) Species: 1280 (Staphylococcus aureus)

MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHAL
TTDEKVHHLTIAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKL
YNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITII
IALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQ
GFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKHTRWNAYSFAA
INTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVAS
FTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYN
DNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILI
DGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEA
AKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILI
LDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIEN
GHIVETGTHRELIAKQGAYEHLYSIQNL

3D structure

• PDB: 2onj Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP.
• Chain: A
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	A	Y349 I356 S376 G377 G378 G379 K380 S381 T382 Q422 E503 H534	Y349 I356 S376 G377 G378 G379 K380 S381 T382 Q422 E503 H534
BS02	ANP	A	K477 S479 G480	K477 S479 G480

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:2onj, PDBe:2onj, PDBj:2onj
• PDBsum: 2onj
• PubMed: 17303126
• UniProt: Q99T13|Y1866_STAAM Putative multidrug export ATP-binding/permease protein SAV1866 (Gene Name=SAV1866)