Structure of PDB 2on3 Chain A

Receptor sequence
>2on3A (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]
EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWL
KALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPE
RIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIA
TVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDAR
CVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSD
SGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCI
LYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGD
WMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQ
3D structure
PDB2on3 A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K63 H181 E258
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XAP A G237 F238 P275 G276 R277 Y389 G221 F222 P259 G260 R261 Y360 PDBbind-CN: -logKd/Ki=9.00,Ki=1.0nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2on3, PDBe:2on3, PDBj:2on3
PDBsum2on3
PubMed17407445
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

[Back to BioLiP]