Structure of PDB 2ol4 Chain A

Receptor sequence
>2ol4A (length=277) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGK
FDNDMIIDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDV
ANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISL
CKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYH
LGRNYNIRINTISAGPLKSTFIDYAIEYSEKYAPLRQKLLSTDIGSVASF
LLSRESRAITGQTIYVDNGLNIMFLPD
3D structure
PDB2ol4 X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy
ChainA
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y277 K285
Catalytic site (residue number reindexed from 1) Y179 K187
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G106 G110 Y111 W131 D168 A169 S215 L216 A217 L265 T266 Y267 K285 A312 P314 L315 S317 G10 G14 Y15 W35 D70 A71 S117 L118 A119 L167 T168 Y169 K187 A214 P216 L217 S219
BS02 JPN A A217 N218 A219 V222 Y267 V274 Y277 F368 A119 N120 A121 V124 Y169 V176 Y179 F221 MOAD: ic50=440nM
BindingDB: IC50=440nM
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ol4, PDBe:2ol4, PDBj:2ol4
PDBsum2ol4
PubMed17567585
UniProtQ9BJJ9

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