Structure of PDB 2okk Chain A

Receptor sequence
>2okkA (length=483) Species: 9606 (Homo sapiens) [Search protein sequence]
NYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHY
PNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLD
MVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDG
IFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKK
GAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAG
TTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERA
NSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHDLSYDTGDKALQCGR
HVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGK
PQHTNVCFWYIPPSLRTLEERMSRLSKVAPVIKARMMEYGTTMVSYQPLG
DKVNFFRMVISNPAATHQDIDFLIEEIERLGQD
3D structure
PDB2okk GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.15: glutamate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU A Q181 L182 S183 R558 Q94 L95 S96 R457
BS02 ABU A L182 H282 X396 L95 H195 X309
Gene Ontology
Molecular Function
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2okk, PDBe:2okk, PDBj:2okk
PDBsum2okk
PubMed17384644
UniProtQ05329|DCE2_HUMAN Glutamate decarboxylase 2 (Gene Name=GAD2)

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