Structure of PDB 2ok5 Chain A

Receptor sequence
>2ok5A (length=710) Species: 9606 (Homo sapiens) [Search protein sequence]
QGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWS
TLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYD
GYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRL
EDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEA
FLSSLTETIKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIE
KVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEGTN
TKKALQAVYSMMSWVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRD
LLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKD
MENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKG
HESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHP
NYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRAL
RLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCE
RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHK
RSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQ
DEDLGFLAAA
3D structure
PDB2ok5 Factor B structure provides insights into activation of the central protease of the complement system.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H501 D551 G672 S674 G675
Catalytic site (residue number reindexed from 1) H469 D519 G640 S642 G643
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A E72 R74 E64 R66
BS02 MAN A K20 K707 K12 K675
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ok5, PDBe:2ok5, PDBj:2ok5
PDBsum2ok5
PubMed17310251
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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