Structure of PDB 2ok1 Chain A

Receptor sequence
>2ok1A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
NQFYSVEVGDSTFTVLKRYQNLKPIGAQGIVCAAYDAVLDRNVAIKKLSR
PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME
LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK
ILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFP
KLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPDEREHTIEEWKELIYKEVMN
3D structure
PDB2ok1 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D142 K144 N147 D160 T166
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 33A A P69 I70 A74 V78 A91 K93 M146 E147 M149 D150 L206 P24 I25 A27 V31 A44 K46 M99 E100 M102 D103 L159 MOAD: Ki=0.55uM
PDBbind-CN: -logKd/Ki=6.26,Ki=0.55uM
BindingDB: Ki=550nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ok1, PDBe:2ok1, PDBj:2ok1
PDBsum2ok1
PubMed17300186
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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