Structure of PDB 2oip Chain A

Receptor sequence

>2oipA (length=516) Species: 237895 (Cryptosporidium hominis)

EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNAL
IMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLM
NDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPE
TFLPVYMSQTFCTKNISYDFMIFEKQEKKNCDPARGQLKSIDDTVDLLGE
IFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRE
NRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNG
NHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKT
MHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVL
SQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGE
LAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIE
LIGYYPYPTIKMDMAV

3D structure

• PDB: 2oip Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UMP	A	R257 C402 Q422 R423 S424 C425 D426 N434 H464 Y466	R252 C397 Q417 R418 S419 C420 D421 N429 H459 Y461
BS02	MTX	A	V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70	V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68
BS03	NDP	A	V10 A11 I19 G23 Q24 L25 G55 R56 K57 T58 I75 S76 S77 R92 C113 G115 E116 S117 T145	V8 A9 I17 G21 Q22 L23 G53 R54 K55 T56 I73 S74 S75 R90 C111 G113 E114 S115 T143
BS04	UMP	A	R382 R383	R377 R378

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 16 06:23:42 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '2oip', asym_id = 'A', title = 'Nonconserved residues Ala287 and Ser290 of the C...se domain facilitate its rapid rate of catalysis '

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='2oip', asym_id='A', title='Nonconserved residues Ala287 and Ser290 of the C...se domain facilitate its rapid rate of catalysis ')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004146,0004799,0006231,0006730,0016741,0046654', uniprot = '', pdbid = '2oip', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004146,0004799,0006231,0006730,0016741,0046654', uniprot='', pdbid='2oip', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>