Structure of PDB 2oi2 Chain A

Receptor sequence
>2oi2A (length=285) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
KVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYE
EDTLSMAVYASLEYLNITEACIRCEIDEKRGMGSSAAISIAAIRAVFDYY
QADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELE
MDLSAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEIAI
SQKDAEGLGQILSQAHLHLKEIGVSSLEADSLVETALSHGALGAKMSGGG
LGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
3D structure
PDB2oi2 Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.36: mevalonate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S92 D135 S85 D128
BS02 DP6 A K13 H20 V22 S92 S132 D135 T175 G255 G256 K10 H17 V19 S85 S125 D128 T168 G248 G249 MOAD: Kd=500nM
PDBbind-CN: -logKd/Ki=6.30,Kd=500nM
Gene Ontology
Molecular Function
GO:0004496 mevalonate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oi2, PDBe:2oi2, PDBj:2oi2
PDBsum2oi2
PubMed17400916
UniProtA0A0H2UNK6

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