Structure of PDB 2ofu Chain A

Receptor sequence
>2ofuA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
PQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG
SMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFL
KTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC
KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI
LLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWK
ERPEDRPTFDYLRSVLEDFFTAT
3D structure
PDB2ofu Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D364 R366 A368 N369 D382 A400 F402
Catalytic site (residue number reindexed from 1) D136 R138 A140 N141 D154 A172 F174
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N9 A L251 V259 A271 K273 E288 T316 Y318 M319 G322 S323 L371 D382 L23 V31 A43 K45 E60 T88 Y90 M91 G94 S95 L143 D154 MOAD: ic50=0.0006uM
PDBbind-CN: -logKd/Ki=9.00,IC50=1nM
BindingDB: IC50=0.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ofu, PDBe:2ofu, PDBj:2ofu
PDBsum2ofu
PubMed16884310
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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