Structure of PDB 2ofi Chain A

Receptor sequence
>2ofiA (length=184) [Search protein sequence]
MQRCDWVSQDPLYIAYHDNEWGVPETDSRKLFEMICLEGQQAGLSWITVL
KKRENYRACFHQFDPIRIAAMQEEDVERLLQNTGIIRHRGKIQAIISNAR
AWLAMEQNGESFADFVWSFVDGQPQITQAASLDKIPTSTPASDALAKALK
KRGFKFVGTTICYSFMQACGLVNDHITGCFCHPG
3D structure
PDB2ofi DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.20: DNA-3-methyladenine glycosylase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L44 T48 I86 R87 K91 L44 T48 I86 R87 K91
BS02 dna A Q41 A42 G43 L44 F156 G158 T160 I161 Q41 A42 G43 L44 F156 G158 T160 I161
BS03 ZN A C4 H17 H175 C179 C4 H17 H175 C179
BS04 ADK A W6 Y13 Y16 W21 E38 W46 S164 W6 Y13 Y16 W21 E38 W46 S164
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2ofi, PDBe:2ofi, PDBj:2ofi
PDBsum2ofi
PubMed17410210
UniProtQ8Z2A5

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