Structure of PDB 2ocf Chain A

Receptor sequence

>2ocfA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR

3D structure

PDB

2ocf Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.

Chain

Resolution

2.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EST	A	L346 E353 M421 H524 L525	L42 E49 M117 H209 L210	BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM

External links

PDB	RCSB:2ocf, PDBe:2ocf, PDBj:2ocf
PDBsum	2ocf
PubMed	11818562
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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