Structure of PDB 2oax Chain A

Receptor sequence
>2oaxA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGF
KNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQA
AFEEMRTNYIKELRKMVTWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRES
HALKVEFPAMLVEIISDQLPKVESGNAKPLYFH
3D structure
PDB2oax Structural basis of spirolactone recognition by the mineralocorticoid receptor
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNL A L766 L769 N770 L772 Q776 M807 L810 L814 F829 M845 L938 F941 C942 T945 F956 L26 L29 N30 L32 Q36 M67 L70 L74 F89 M105 L189 F192 C193 T196 F207 PDBbind-CN: -logKd/Ki=8.65,Ki=2.232nM
BindingDB: IC50=11nM,Ki=2.323nM
External links
PDB RCSB:2oax, PDBe:2oax, PDBj:2oax
PDBsum2oax
PubMed17569793
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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