Structure of PDB 2oa8 Chain A

Receptor sequence
>2oa8A (length=220) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTQGHPPPV
PRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAIL
LRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIA
ALKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQAL
LQWVDEHARPFSTVKPMYGT
3D structure
PDB2oa8 The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 G23 L24 G80 A81 I84 H124 N125 R128 Y129 I156 S176 Y177 S178 L179 E16 A17 G19 L20 G73 A74 I77 H117 N118 R121 Y122 I149 S161 Y162 S163 L164
BS02 CA A D18 E20 H195 D200 D14 E16 H180 D185
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2oa8, PDBe:2oa8, PDBj:2oa8
PDBsum2oa8
PubMed17293595
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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