Structure of PDB 2oa0 Chain A

Receptor sequence
>2oa0A (length=980) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW
ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI
VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV
NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ
QKLDEFGEQLSKVISLICVAVWLINHGGSWIRGAIYYFKIAVALAVAAIP
EGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTT
NQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFD
GLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTE
VRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAV
GNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGRDT
LRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKEVM
GSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREF
DDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDA
PALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK
QFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALG
FNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMY
AEDGPGVTYHQLTHFMQCTEDHPHEIFEAPEPMTMALSVLVTIEMCNALN
SLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLKALDL
TQWLMVLKISLPVIGLDEILKFIARNYLEG
3D structure
PDB2oa0 The molecular basis for cyclopiazonic Acid inhibition of the sarcoplasmic reticulum calcium pump.
ChainA
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D351 D703 D707
Catalytic site (residue number reindexed from 1) D343 D695 D699
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CZA A Q56 L61 V62 L98 N101 A102 E309 L311 P312 Q56 L61 V62 L98 N101 A102 E301 L303 P304 PDBbind-CN: -logKd/Ki=6.92,Ki=120nM
BS02 ADP A T353 R489 K492 T625 G626 R678 T345 R481 K484 T617 G618 R670
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0070588 calcium ion transmembrane transport
GO:0106134 positive regulation of cardiac muscle cell contraction
GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
GO:1990036 calcium ion import into sarcoplasmic reticulum
Cellular Component
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oa0, PDBe:2oa0, PDBj:2oa0
PDBsum2oa0
PubMed17259168
UniProtP04191|AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Gene Name=ATP2A1)

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