BioLiP

>2o8bA (length=831) Species: 9606 (Homo sapiens) [Search protein sequence]

MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDA
LLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRV
EVYKNRAGSKENDWYLAYKASPGNLSQFEDILFGNNIGVVGVKMSAVDGQ
RQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAG
DMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRGKKGEQMNSAVLPEM
ENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALN
LFQGSTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEA
FVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLP
NVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVEN
HEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDS
SAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTK
NKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGA
PVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFH
IITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGST
FMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKI
GAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQ
SFGIHVAELANFPKHVIECAKQKALELEEFQ

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

I648 F650 I651 N671 M672 G674 K675 S676 T677 Y815

I633 F635 I636 N656 M657 G659 K660 S661 T662 Y791

Molecular Function

GO:0000287

magnesium ion binding

GO:0000400

four-way junction DNA binding

DNA binding

chromatin binding

damaged DNA binding

double-stranded DNA binding

GO:0003697

single-stranded DNA binding

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0008094

ATP-dependent activity, acting on DNA

GO:0016887

ATP hydrolysis activity

GO:0019237

centromeric DNA binding

GO:0030983

mismatched DNA binding

GO:0032137

guanine/thymine mispair binding

GO:0032139

dinucleotide insertion or deletion binding

GO:0032142

single guanine insertion binding

GO:0032143

single thymine insertion binding

GO:0032181

dinucleotide repeat insertion binding

GO:0032357

oxidized purine DNA binding

GO:0032405

MutLalpha complex binding

GO:0042803

protein homodimerization activity

GO:0043531

ADP binding

GO:0140664

ATP-dependent DNA damage sensor activity

	Biological Process
GO:0001701	in utero embryonic development
GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
GO:0006119	oxidative phosphorylation
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006301	postreplication repair
GO:0006302	double-strand break repair
GO:0006312	mitotic recombination
GO:0006974	DNA damage response
GO:0007281	germ cell development
GO:0008340	determination of adult lifespan
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165	response to X-ray
GO:0010224	response to UV-B
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0019724	B cell mediated immunity
GO:0030183	B cell differentiation
GO:0031573	mitotic intra-S DNA damage checkpoint signaling
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043524	negative regulation of neuron apoptotic process
GO:0043570	maintenance of DNA repeat elements
GO:0045190	isotype switching
GO:0045910	negative regulation of DNA recombination
GO:0048298	positive regulation of isotype switching to IgA isotypes
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0051096	positive regulation of helicase activity
GO:0051726	regulation of cell cycle
GO:0071168	protein localization to chromatin

Biological Process

GO:0001701

in utero embryonic development

GO:0002204

somatic recombination of immunoglobulin genes involved in immune response

GO:0006119

oxidative phosphorylation

GO:0006281

DNA repair

GO:0006298

mismatch repair

GO:0006301

postreplication repair

GO:0006302

double-strand break repair

GO:0006312

mitotic recombination

GO:0006974

DNA damage response

GO:0007281

germ cell development

GO:0008340

determination of adult lifespan

GO:0008584

male gonad development

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

GO:0010165

response to X-ray

GO:0010224

response to UV-B

GO:0016446

somatic hypermutation of immunoglobulin genes

GO:0016447

somatic recombination of immunoglobulin gene segments

GO:0019724

B cell mediated immunity

GO:0030183

B cell differentiation

GO:0031573

mitotic intra-S DNA damage checkpoint signaling

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO:0043524

negative regulation of neuron apoptotic process

GO:0043570

maintenance of DNA repeat elements

GO:0045190

isotype switching

GO:0045910

negative regulation of DNA recombination

GO:0048298

positive regulation of isotype switching to IgA isotypes

GO:0048304

positive regulation of isotype switching to IgG isotypes

GO:0051096

positive regulation of helicase activity

GO:0051726

regulation of cell cycle

GO:0071168

protein localization to chromatin

	Cellular Component
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0016020	membrane
GO:0032301	MutSalpha complex
GO:0032302	MutSbeta complex

Cellular Component

GO:0000781

chromosome, telomeric region

nucleus

nucleoplasm

chromosome

membrane

MutSalpha complex

MutSbeta complex

PDB	RCSB:2o8b, PDBe:2o8b, PDBj:2o8b
PDBsum	2o8b
PubMed	17531815
UniProt	P43246\|MSH2_HUMAN DNA mismatch repair protein Msh2 (Gene Name=MSH2)

Structure of PDB 2o8b Chain A