Structure of PDB 2o4p Chain A

Receptor sequence

>2o4pA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

3D structure

PDB

2o4p Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.

Chain

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPV	A	R8 D25 A28 D29 D30 G48 G49 I50 V82	R8 D25 A28 D29 D30 G48 G49 I50 V82	MOAD: Kd=19pM PDBbind-CN: -logKd/Ki=10.72,Kd=19pM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

External links