Structure of PDB 2o4j Chain A

Receptor sequence
>2o4jA (length=240) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMPLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMS
WDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMA
ICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQ
KLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNE
3D structure
PDB2o4j New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 Q255 I256 K260 P412 E416 I57 K61 Q74 I75 K79 P231 E235
BS02 VD4 A Y143 V230 S233 R270 S271 S274 W282 C284 H301 H393 Y21 V49 S52 R89 S90 S93 W101 C103 H120 H212 MOAD: Ki=0.08nM
PDBbind-CN: -logKd/Ki=10.10,Ki=0.08nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2o4j, PDBe:2o4j, PDBj:2o4j
PDBsum2o4j
PubMed17227670
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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