Structure of PDB 2o4c Chain A

Receptor sequence
>2o4cA (length=380) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVS
RAALAGSPVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVL
GCLLAMAEVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQ
AREPDGEFVSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPG
TWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQADPELAARCLI
ATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQL
NPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALRKHYP
PRREITGLRVATGGQAELQRVVRALGAQLV
3D structure
PDB2o4c Crystal Structure of d-Erythronate-4-phosphate Dehydrogenase Complexed with NAD
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N91 R208 D232 E237 H254
Catalytic site (residue number reindexed from 1) N91 R208 D232 E237 H254
Enzyme Commision number 1.1.1.290: 4-phosphoerythronate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A T66 R346 T66 R346
BS02 NAD A N91 V95 G123 G125 Q126 V127 D146 P147 P148 H174 T175 P176 H183 T185 A206 S207 H254 A256 G257 N91 V95 G123 G125 Q126 V127 D146 P147 P148 H174 T175 P176 H183 T185 A206 S207 H254 A256 G257
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0033711 4-phosphoerythronate dehydrogenase activity
GO:0046983 protein dimerization activity
GO:0051287 NAD binding
Biological Process
GO:0008615 pyridoxine biosynthetic process
GO:0036001 'de novo' pyridoxal 5'-phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o4c, PDBe:2o4c, PDBj:2o4c
PDBsum2o4c
PubMed17217963
UniProtQ9I3W9|PDXB_PSEAE Erythronate-4-phosphate dehydrogenase (Gene Name=pdxB)

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