Structure of PDB 2o3e Chain A

Receptor sequence
>2o3eA (length=665) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MSSYTAAGRNVLRWDLSPEQIKTRTEQLIAQTKQVYDTVGTIALKEVTYE
NCLQVLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEM
SMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLSEHIRN
EIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDE
DKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPL
RAQVAKLLGYNTHADFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREF
ILSLKKKECEERGFEYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPI
EVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFY
LDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPVAGRPSL
LRHDEVETYFHEFGHVMHQICAQTDFARFSGTNVERDFVEVPSQMLENWV
WDVDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQ
SLHTNATLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGY
LWSEVFSMDMFHSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFL
QREPNQKAFLMSRGL
3D structure
PDB2o3e Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H474 E475 H478 E503 Y613
Catalytic site (residue number reindexed from 1) H461 E462 H465 E490 Y600
Enzyme Commision number 3.4.24.16: neurolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H474 H478 E503 H461 H465 E490
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0030163 protein catabolic process
GO:0043171 peptide catabolic process
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2o3e, PDBe:2o3e, PDBj:2o3e
PDBsum2o3e
PubMed17251185
UniProtP42676|NEUL_RAT Neurolysin, mitochondrial (Gene Name=Nln)

[Back to BioLiP]