Structure of PDB 2o22 Chain A

Receptor sequence
>2o22A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
HAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDDVEENRTEAPEGTESEVV
HLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN
WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNG
GWDAFVELYGPSMR
3D structure
PDB2o22 Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LIU A A97 D100 F101 Y105 D108 F109 G142 V145 A146 F195 Y199 A57 D60 F61 Y65 D68 F69 G102 V105 A106 F155 Y159 PDBbind-CN: -logKd/Ki=7.17,Ki=67nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:2o22, PDBe:2o22, PDBj:2o22
PDBsum2o22
PubMed17256834
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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