Structure of PDB 2o19 Chain A

Receptor sequence
>2o19A (length=630) Species: 562 (Escherichia coli) [Search protein sequence]
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQ
PDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVH
AGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLR
SNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQT
PVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQ
DEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIE
AAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNA
ISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA
KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLL
GSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAM
TGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHS
TDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY
QLIDQAKRTPVRQFRGIEVGSGAIAHHHHH
3D structure
PDB2o19 Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E7 D105 E107
Catalytic site (residue number reindexed from 1) E7 D105 E107
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K8 P51 W61 D103 R165 D169 W170 G173 R178 R185 S194 V195 G196 V198 Q199 R330 T524 T527 R538 K8 P51 W61 D103 R165 D169 W170 G173 R178 R185 S194 V195 G196 V198 Q199 R330 T524 T527 R538
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0098847 sequence-specific single stranded DNA binding
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051304 chromosome separation
Cellular Component
GO:0043597 cytoplasmic replication fork

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o19, PDBe:2o19, PDBj:2o19
PDBsum2o19
PubMed17331537
UniProtP14294|TOP3_ECOLI DNA topoisomerase 3 (Gene Name=topB)

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