Structure of PDB 2o0l Chain A

Receptor sequence
>2o0lA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
IREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVL
DGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHP
SVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQD
AFDVIITDSSESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQS
LFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQL
KYYNSDVHRAAFVLPEFARKALND
3D structure
PDB2o0l Structure and mechanism of spermidine synthases.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A Q70 Q80 G101 G103 D104 E124 I125 D155 G156 D173 S175 Q55 Q65 G86 G88 D89 E109 I110 D140 G141 D158 S160
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o0l, PDBe:2o0l, PDBj:2o0l
PDBsum2o0l
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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