Structure of PDB 2o07 Chain A

Receptor sequence
>2o07A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
IREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVL
DGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHP
SVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQD
AFDVIITDSSESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQS
LFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQL
KYYNSDVHRAAFVLPEFARKALND
3D structure
PDB2o07 Structure and mechanism of spermidine synthases.
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SPD A V68 I69 Q70 Y79 D173 S174 Y241 P242 V53 I54 Q55 Y64 D158 S159 Y215 P216
BS02 MTA A G101 G103 D104 E124 I125 G154 D155 G156 S175 G86 G88 D89 E109 I110 G139 D140 G141 S160
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o07, PDBe:2o07, PDBj:2o07
PDBsum2o07
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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