Structure of PDB 2o06 Chain A

Receptor sequence
>2o06A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
DGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFR
SKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDG
GVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGD
GFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCC
QGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNP
STNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
3D structure
PDB2o06 Structure and mechanism of spermidine synthases.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A H91 D168 D200 G201 H86 D163 D195 G196
BS02 MTA A G101 G102 G103 D104 E124 I125 D155 G156 D173 P180 A181 G96 G97 G98 D99 E119 I120 D150 G151 D168 P175 A176
BS03 PUT A S174 D176 Y241 S169 D171 Y236
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o06, PDBe:2o06, PDBj:2o06
PDBsum2o06
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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