Structure of PDB 2o05 Chain A

Receptor sequence
>2o05A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
AIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLV
LDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKH
PSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQ
DAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHL
DLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQ
PLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
3D structure
PDB2o05 Structure and mechanism of spermidine synthases.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A G101 G102 D104 E124 I125 G154 D155 G156 D173 S175 P180 A181 L184 G87 G88 D90 E110 I111 G140 D141 G142 D159 S161 P166 A167 L170
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o05, PDBe:2o05, PDBj:2o05
PDBsum2o05
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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