Structure of PDB 2nx8 Chain A

Receptor sequence
>2nx8A (length=168) Species: 301450 (Streptococcus pyogenes serotype M6) [Search protein sequence]
SFLMPYSLEEQTYFMQEALKESEKSLQKAEIPIGCVIVKDGEIIGRGHNA
REESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLA
RIPHVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQT
FFRQGRERKKIAKHLIKE
3D structure
PDB2nx8 Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H65 E67 E93 C95 C98
Catalytic site (residue number reindexed from 1) H60 E62 E88 C90 C93
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H65 C95 C98 H60 C90 C93
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0008033 tRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2nx8, PDBe:2nx8, PDBj:2nx8
PDBsum2nx8
PubMed17554781
UniProtQ5XE14|TADA_STRP6 tRNA-specific adenosine deaminase (Gene Name=tadA)

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