Structure of PDB 2nwn Chain A

Receptor sequence
>2nwnA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRSVTYVCGGSLISPCWVISATHCFIDYPKK
EDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSALAHHNDIALLKIRSK
EGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYPEQLKM
TVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSL
QGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB2nwn Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D91 Q189 G190 D191 S192 G193
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R35 H57 C58 D60A Y60B L97B H99 D189 S190 C191 Q192 S195 S214 W215 R217 G219 R20 H42 C43 D46 Y47 L86 H88 D186 S187 C188 Q189 S192 S211 W212 R214 G215
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2nwn, PDBe:2nwn, PDBj:2nwn
PDBsum2nwn
PubMed17692534
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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