Structure of PDB 2nr9 Chain A

Receptor sequence
>2nr9A (length=192) Species: 281310 (Haemophilus influenzae 86-028NP) [Search protein sequence]
FLAQQGKITLILTALCVLIYIAQQLGFEDDIMYLMHYPAYEEQDSEVWRY
ISHTLVHLSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYV
QNYVSGPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIAL
GFISPLFGVEMGNAAHISGLIVGLIWGFIDSKLRKNSLELVP
3D structure
PDB2nr9 The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PA6 A I182 L186 I179 L183
BS02 PQE A N166 W179 I182 N163 W176 I179
BS03 PQE A S62 N63 I75 S59 N60 I72
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nr9, PDBe:2nr9, PDBj:2nr9
PDBsum2nr9
PubMed17210913
UniProtP44783|GLPG_HAEIN Rhomboid protease GlpG (Gene Name=glpG)

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