Structure of PDB 2nq7 Chain A

Receptor sequence
>2nq7A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKL
LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHA
QANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI
CEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARP
HFMS
3D structure
PDB2nq7 Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D229 D240 H303 H310 E336 E367
Catalytic site (residue number reindexed from 1) D140 D151 H214 H221 E247 E278
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A D229 D240 E367 D140 D151 E278
BS02 CO A D240 H303 T334 E336 E367 D151 H214 T245 E247 E278
BS03 HM5 A P192 Y195 Y196 F198 C203 H212 H310 W353 P103 Y106 Y107 F109 C114 H123 H221 W264 MOAD: ic50=2.9uM
PDBbind-CN: -logKd/Ki=5.54,IC50=2.9uM
BindingDB: IC50=2900nM
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2nq7, PDBe:2nq7, PDBj:2nq7
PDBsum2nq7
PubMed17114291
UniProtP53582|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)

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