Structure of PDB 2npa Chain A

Receptor sequence
>2npaA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGAASNNPPFVIHDMETLC
MAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFA
NLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLR
KPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIE
KMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIK
KTESDAALHPLLQEIYRDM
3D structure
PDB2npa Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T288 K292 L302 N303 V306 L309 K310 E462 T90 K94 L104 N105 V108 L111 K112 E264
BS02 MMB A F273 C275 C276 S280 Y314 L321 M330 V332 I354 M355 H440 Y464 F75 C77 C78 S82 Y116 L123 M132 V134 I156 M157 H242 Y266 BindingDB: EC50=19nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:2npa, PDBe:2npa, PDBj:2npa
PDBsum2npa
PubMed17157019
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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