Structure of PDB 2np8 Chain A

Receptor sequence
>2np8A (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
WSVHAPSSRTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN
TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW
ITANSS
3D structure
PDB2np8 Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CC3 A L139 G142 K143 V147 A160 L194 A213 P214 G216 L263 L13 G16 K17 V21 A34 L68 A87 P88 G90 L137 MOAD: ic50=42nM
PDBbind-CN: -logKd/Ki=7.38,IC50=42nM
BindingDB: IC50=42nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:2np8, PDBe:2np8, PDBj:2np8
PDBsum2np8
PubMed17157005
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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