Structure of PDB 2nod Chain A

Receptor sequence
>2nodA (length=414) Species: 10090 (Mus musculus) [Search protein sequence]
QYVRIKNWGSGEILHDTLHHKATSDSCLGSIMNPKSLTRGPRDKPTPLEE
LLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIF
ATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNG
NIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQ
LCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEW
FQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQR
YNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHT
ASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPF
YYYQIEPWKTHIWQ
3D structure
PDB2nod Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C194 R197 W366 E371
Catalytic site (residue number reindexed from 1) C112 R115 W284 E289
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A W188 C194 F363 N364 G365 W366 E371 W457 Y485 W106 C112 F281 N282 G283 W284 E289 W375 Y403
BS02 H4B A S112 R375 I456 W457 S30 R293 I374 W375
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2nod, PDBe:2nod, PDBj:2nod
PDBsum2nod
PubMed9516116
UniProtP29477|NOS2_MOUSE Nitric oxide synthase, inducible (Gene Name=Nos2)

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