Structure of PDB 2n7b Chain A

Receptor sequence
>2n7bA (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
MEGDRQYGDGYLLQVQELVTVQEGLSVHVPCSFSYPQDGWTDSDPVHGYW
FRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARK
RDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHGSLVPR
3D structure
PDB2n7b Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6S A R56 Y58 Q59 R56 Y58 Q59 PDBbind-CN: -logKd/Ki=3.55,Kd=279uM
BS02 SIA A Y7 Y11 Y58 R109 K116 W117 S118 Q122 Y7 Y11 Y58 R109 K116 W117 S118 Q122 PDBbind-CN: -logKd/Ki=3.55,Kd=279uM
External links
PDB RCSB:2n7b, PDBe:2n7b, PDBj:2n7b
PDBsum2n7b
PubMed27357658
UniProtQ9NYZ4|SIGL8_HUMAN Sialic acid-binding Ig-like lectin 8 (Gene Name=SIGLEC8)

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