Structure of PDB 2n02 Chain A

Receptor sequence
>2n02A (length=169) Species: 10090 (Mus musculus) [Search protein sequence]
MPESWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYAGLQKPSWHPPRWTLA
PIWGTLYSAMGYGSYIVWKELGGFTEDAMVPLGLYTGQLALNWAWPPIFF
GARQMGWALADLLLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFTTVL
NYYVWRDNSGRRGGSRLAE
3D structure
PDB2n02 Structural Integrity of the A147T Polymorph of Mammalian TSPO.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PKA A G19 G22 A23 K39 H43 R46 L49 W53 W107 A110 W143 N151 G19 G22 A23 K39 H43 R46 L49 W53 W107 A110 W143 N151
Gene Ontology
Molecular Function
GO:0005497 androgen binding
GO:0008503 benzodiazepine receptor activity
GO:0044325 transmembrane transporter binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0008347 glial cell migration
GO:0009410 response to xenobiotic stimulus
GO:0010042 response to manganese ion
GO:0010266 response to vitamin B1
GO:0014012 peripheral nervous system axon regeneration
GO:0030325 adrenal gland development
GO:0031397 negative regulation of protein ubiquitination
GO:0032570 response to progesterone
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033574 response to testosterone
GO:0042632 cholesterol homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0048678 response to axon injury
GO:0050810 regulation of steroid biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0060242 contact inhibition
GO:0060252 positive regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0062100 positive regulation of programmed necrotic cell death
GO:0071222 cellular response to lipopolysaccharide
GO:0071294 cellular response to zinc ion
GO:0071476 cellular hypotonic response
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:1901525 negative regulation of mitophagy
GO:1903579 negative regulation of ATP metabolic process
GO:1905144 response to acetylcholine
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000853 negative regulation of corticosterone secretion
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2n02, PDBe:2n02, PDBj:2n02
PDBsum2n02
PubMed25974690
UniProtP50637|TSPO_MOUSE Translocator protein (Gene Name=Tspo)

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