Structure of PDB 2mps Chain A

Receptor sequence
>2mpsA (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
NTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKE
VLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM
IYRNLVV
3D structure
PDB2mps Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K51 L54 G58 I61 M62 Q72 F91 V93 K94 H96 I99 Y100 K49 L52 G56 I59 M60 Q70 F89 V91 K92 H94 I97 Y98
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2mps, PDBe:2mps, PDBj:2mps
PDBsum2mps
PubMed25591003
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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