Structure of PDB 2mlm Chain A

Receptor sequence

>2mlmA (length=148) Species: 1323661 (Staphylococcus aureus CA-347) [Search protein sequence]

MQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENE
SLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSI
RDVKPTDVEVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK

3D structure

PDB

2mlm Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase.

Chain

Resolution

N/A

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2W7	A	V108 E113 I124 C126 W136 R139	V108 E113 I124 C126 W136 R139	PDBbind-CN: -logKd/Ki=5.21,IC50=6.11uM

External links

PDB	RCSB:2mlm, PDBe:2mlm, PDBj:2mlm
PDBsum	2mlm
PubMed	25282649

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