Structure of PDB 2m9q Chain A

Receptor sequence
>2m9qA (length=240) Species: 413041 (Dengue virus 2 Thailand/0168/1979) [Search protein sequence]
GSAADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTL
GGGGSGGGGEFAGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAG
VYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEW
KEGEEVQVLALEPGKNPRAVQTKPGLFKTNAGTIGAVSLDFSPGTSGSPI
IDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIE
3D structure
PDB2m9q NMR structure of an inhibitor bound dengue NS3 protease provides new insights into the NS2B NS3 ligand interactions
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L6 E7 E45 E47 Q48 L50 I86 K87 Q88 G90 I91 L92 G93 S95 Q96 I97 H112 V113 T114 L119 P193 S196 L6 E7 E45 E47 Q48 L50 I86 K87 Q88 G90 I91 L92 G93 S95 Q96 I97 H112 V113 T114 L119 P193 S196
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:2m9q, PDBe:2m9q, PDBj:2m9q
PDBsum2m9q
PubMed
UniProtP14337|POLG_DEN28 Genome polyprotein

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