Structure of PDB 2m9p Chain A

Receptor sequence
>2m9pA (length=240) Species: 413041 (Dengue virus 2 Thailand/0168/1979) [Search protein sequence]
GSAADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTL
GGGGSGGGGEFAGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAG
VYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEW
KEGEEVQVLALEPGKNPRAVQTKPGLFKTNAGTIGAVSLDFSPGTSGSPI
IDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIE
3D structure
PDB2m9p NMR structure of an inhibitor bound dengue NS3 protease provides new insights into the NS2B NS3 ligand interactions
ChainA
ResolutionN/A
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E44 E45 E46 E47 Q48 T49 I97 H112 V113 S196 G212 V215 V216 S219 S224 E44 E45 E46 E47 Q48 T49 I97 H112 V113 S196 G212 V215 V216 S219 S224
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:2m9p, PDBe:2m9p, PDBj:2m9p
PDBsum2m9p
PubMed
UniProtP14337|POLG_DEN28 Genome polyprotein

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