Structure of PDB 2m04 Chain A

Receptor sequence
>2m04A (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
MSAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAVK
QALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNW
GRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGG
WDTFVELYGNNAAAESRKGQERLE
3D structure
PDB2m04 PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F97 L99 R103 A104 D107 L108 S110 Q111 H113 T118 Q121 S122 V126 E129 R132 D133 G134 N136 W137 G138 R139 A142 F146 A199 F60 L62 R66 A67 D70 L71 S73 Q74 H76 T81 Q84 S85 V89 E92 R95 D96 G97 N99 W100 G101 R102 A105 F109 A162
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:2m04, PDBe:2m04, PDBj:2m04
PDBsum2m04
PubMed23340338
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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