Structure of PDB 2lzg Chain A

Receptor sequence
>2lzgA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTM
KEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIY
TMIYRNLVVVNQQESSDSGTSVSEN
3D structure
PDB2lzg Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 13Q A V14 T16 L54 G58 I61 Y67 V93 H96 V14 T16 L54 G58 I61 Y67 V93 H96 PDBbind-CN: -logKd/Ki=7.77,Kd=16.9nM
BindingDB: IC50=34nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2lzg, PDBe:2lzg, PDBj:2lzg
PDBsum2lzg
PubMed22991965
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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