Structure of PDB 2lwi Chain A

Receptor sequence
>2lwiA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPSIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB2lwi In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G12 G13 G15 N116 K117 L120 A146 K147 G12 G13 G15 N116 K117 L120 A146 K147
BS02 KOB A L56 A66 M67 Q70 Y71 L56 A66 M67 Q70 Y71 PDBbind-CN: -logKd/Ki=3.11,Ki=773uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2lwi, PDBe:2lwi, PDBj:2lwi
PDBsum2lwi
PubMed23630290
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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