Structure of PDB 2lkx Chain A

Receptor sequence
>2lkxA (length=68) Species: 9606 (Homo sapiens) [Search protein sequence]
GSQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVW
FKNRRAKWRKREEFIVTD
3D structure
PDB2lkx Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R3 R5 T6 K50 N51 R52 K55 R59 R5 R7 T8 K52 N53 R54 K57 R61 PDBbind-CN: Kd=2.6nM
BS02 dna A R2 R3 R5 Y25 M28 R31 K50 R53 R57 R4 R5 R7 Y27 M30 R33 K52 R55 R59 PDBbind-CN: Kd=2.6nM
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2lkx, PDBe:2lkx, PDBj:2lkx
PDBsum2lkx
PubMed15895993
UniProtQ99697|PITX2_HUMAN Pituitary homeobox 2 (Gene Name=PITX2)

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