Structure of PDB 2lkk Chain A

Receptor sequence
>2lkkA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFT
ITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSV
TELNGDIITNTMTLGDIVFKRISKRI
3D structure
PDB2lkk Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OLA A F15 M19 L28 K31 A54 S56 M74 F14 M18 L27 K30 A53 S55 M73 PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM
BindingDB: Kd=900nM
BS02 OLA A S39 F50 E72 F95 N111 M113 R122 S124 S38 F49 E71 F94 N110 M112 R121 S123 PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM
BindingDB: Kd=900nM
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005324 long-chain fatty acid transmembrane transporter activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0016209 antioxidant activity
GO:0032052 bile acid binding
GO:0070538 oleic acid binding
GO:1901363 heterocyclic compound binding
Biological Process
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0033552 response to vitamin B3
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050892 intestinal absorption
GO:0070301 cellular response to hydrogen peroxide
GO:0071456 cellular response to hypoxia
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0045179 apical cortex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2lkk, PDBe:2lkk, PDBj:2lkk
PDBsum2lkk
PubMed22713574
UniProtP07148|FABPL_HUMAN Fatty acid-binding protein, liver (Gene Name=FABP1)

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